The accuracy and feasibility of skeletal muscle measured by semi-automatic three-dimensional MRI VOI method: A study using pig forelimbs

Main Article Content

Qing-Qing Zhou
Qian-Qian Hu
Xianfeng Yang https://orcid.org/0000-0001-5145-7949
Yu-Chen Chen
Yu-Sheng Yu
Jue Zhang
Qinghong Ma
Gang-Ping Zhou
Hengle Wei
Bing Zhang
Hong Zhang

Keywords

Magnetic Resonance Imaging; Skeletal Muscle; Dimensional Measurement Accuracy; muscular atrophy; Pigs

Abstract

Rationale and Objectives: We aimed to assess and verify the measurement accuracy and feasibility of semi-automatic MRI volume of interest (VOI) method by comparing its measurements with actual skeletal muscle volumes and discussed the clinical significance.


Methods: A total of 18 muscles from two pigs were measured by drainage method, VOI method (VVOI), the summation method (Vsum) and maximum section method (Vmax) respectively after MRI scanning. All these methods were operated by two musculoskeletal radiologists and repeated at 6 different times, recording the consuming time (minutes) of every muscle. The average result of the two radiologists was adopted.


Results: The 3D structure of skeletal muscle was distinct and vivid. Friedman test and the interclass ICC indicated the VOI method had a high intra-and inter reliability. Root mean square error (RMSE) in 6 time points was 1.101 ml. Bland-Altman plot represented a superior consistency. Pairwise Mann–Whitney U test demonstrated the consuming time to measure each muscle by VOI method was short.


Conclusions: The VOI method could semi-automatically display the 3D reconstruct of skeletal muscle clearly, conveniently, with a great accuracy and high repeatability.


Rationale and Objectives: We aimed to assess and verify the measurement accuracy and feasibility of semi-automatic MRI volume of interest (VOI) method by comparing its measurements with actual skeletal muscle volumes and discussed the clinical significance.


Methods: A total of 18 muscles from two pigs were measured by drainage method, VOI method (VVOI), the summation method (Vsum) and maximum section method (Vmax) respectively after MRI scanning. All these methods were operated by two musculoskeletal radiologists and repeated at 6 different times, recording the consuming time (minutes) of every muscle. The average result of the two radiologists was adopted.


Results: The 3D structure of skeletal muscle was distinct and vivid. Friedman test and the interclass ICC indicated the VOI method had a high intra-and inter reliability. Root mean square error (RMSE) in 6 time points was 1.101 ml. Bland-Altman plot represented a superior consistency. Pairwise Mann–Whitney U test demonstrated the consuming time to measure each muscle by VOI method was short.


Conclusions: The VOI method could semi-automatically display the 3D reconstruct of skeletal muscle clearly, conveniently, with a great accuracy and high repeatability.

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